Regression of left ventricular hypertrophy provides an additive physiological benefit following treatment of aortic stenosis: Insights from serial coronary wave intensity analysis.
Christopher J BroydFausto RigoSukhjinder NijjerSayan SenRicardo PetracoRasha Al-LameeNicolas FoinAndrew ChukwuemekaJon AndersonJessica ParkerIqbal S MalikGhada W MikhailDarrel P FrancisKim ParkerAlun D HughesJamil MayetJustin E DaviesPublished in: Acta physiologica (Oxford, England) (2018)
In aortic stenosis, both the outflow tract gradient and the presence of LVH impact significantly on coronary haemodynamics that cannot be appreciated by examining resting coronary flow rates alone. An immediate change in coronary wave intensity occurs following intervention with further effects appreciable with hypertrophy regression. The improvement in prognosis with treatment is likely to be attributable to both features.
Keyphrases
- aortic stenosis
- left ventricular
- transcatheter aortic valve replacement
- ejection fraction
- aortic valve replacement
- aortic valve
- transcatheter aortic valve implantation
- coronary artery disease
- coronary artery
- randomized controlled trial
- heart failure
- hypertrophic cardiomyopathy
- acute myocardial infarction
- percutaneous coronary intervention
- high intensity
- mitral valve
- heart rate
- smoking cessation
- acute coronary syndrome
- heart rate variability
- replacement therapy