Functional and structural reverse myocardial remodeling following transcatheter aortic valve replacement: a prospective cardiovascular magnetic resonance study.
Torben LangeSören J BackhausBo Eric BeuthnerRodi TopciKarl-Rudolf RigorthJohannes T KowallickRuben EvertzMoritz SchnelleSusana RavassaJavier DíezKarl ToischerTim SeidlerMiriam PulsGerd HasenfußAndreas SchusterPublished in: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance (2022)
CMR imaging enables comprehensive detection of myocardial remodeling in patients undergoing TAVR. Regression of LV matrix volume as a surrogate for reversible diffuse myocardial fibrosis is accompanied by increase of myocardial function and recovery from heart failure. Further data are required to define the value of these parameters as therapeutic targets for optimized management of TAVR patients. Trial registration DRKS, DRKS00024479. Registered 10 December 2021-Retrospectively registered, https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00024479.
Keyphrases
- transcatheter aortic valve replacement
- left ventricular
- aortic stenosis
- aortic valve
- ejection fraction
- heart failure
- magnetic resonance
- phase iii
- study protocol
- patients undergoing
- end stage renal disease
- clinical trial
- phase ii
- chronic kidney disease
- newly diagnosed
- prognostic factors
- randomized controlled trial
- electronic health record
- computed tomography
- magnetic resonance imaging
- patient reported outcomes
- peritoneal dialysis
- photodynamic therapy
- machine learning
- loop mediated isothermal amplification
- mass spectrometry
- atrial fibrillation
- quantum dots
- liver fibrosis
- sensitive detection
- fluorescence imaging