The Effects of Physical Activity on Experimental Models of Vascular Dementia: A Systematic Review and Meta-Analysis.
Ifechukwude Joachim BioseWesley H ChastainRebecca J Solch-OttaianoViktoriya S GraysonHanyun WangSomdeb BanerjeeGregory J BixPublished in: Annals of neurosciences (2024)
Exercise improved cognitive function as well as some markers of brain morphology in models of VaD. However, exercise increased anxiety and neuro-inflammatory signals in VaD models. Further, we observed increased reporting anomalies such as a lack of blinding to group treatment or data analysis and randomization of animals to groups. Our report could help in the appropriate design of experimental studies seeking to investigate the effects of exercise as a non-pharmacological intervention on VaD models with a high translational impact.
Keyphrases
- physical activity
- data analysis
- high intensity
- randomized controlled trial
- resistance training
- mild cognitive impairment
- body mass index
- mental health
- emergency department
- oxidative stress
- body composition
- sleep quality
- multiple sclerosis
- white matter
- brain injury
- subarachnoid hemorrhage
- cerebral ischemia
- drug induced