Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay.

Maria Pia AbruzzeseMaria Teresa BilottaCinzia FiondaAlessandra ZingoniAlessandra SorianiElisabetta VulpisCristiana BorrelliBeatrice ZittiMaria Teresa PetrucciMaria Rosaria RicciardiRosa MolfettaRossella PaoliniAngela SantoniMarco Cippitelli

Published in: Journal of hematology & oncology (2016)

These findings provide new insights on the immuno-mediated antitumor activities of BETi and further elucidate the molecular mechanisms that regulate NK cell-activating ligand expression in MM.

Keyphrases

nk cells
poor prognosis
multiple myeloma
induced apoptosis
signaling pathway
cell cycle arrest
binding protein
long non coding rna
dendritic cells
cell death
natural killer cells