Regulatory miRNAs and lncRNAs in Skin Cancer: A Narrative Review.
Nicole NatarelliAleena BobyShaliz AflatooniJasmine Thuy TranMichael Joseph DiazKamil TanejaMahtab ForouzandehPublished in: Life (Basel, Switzerland) (2023)
Non-coding RNAs (ncRNAs) have a significant regulatory role in the pathogenesis of skin cancer, despite the fact that protein-coding genes have generally been the focus of research efforts in the field. We comment on the actions of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in the current review with an eye toward potential therapeutic treatments. LncRNAs are remarkably adaptable, acting as scaffolding, guides, or decoys to modify key signaling pathways (i.e., the Wnt/β-catenin pathway) and gene expression. As post-transcriptional gatekeepers, miRNAs control gene expression by attaching to messenger RNAs and causing their degradation or suppression during translation. Cell cycle regulation, cellular differentiation, and immunological responses are all affected by the dysregulation of miRNAs observed in skin cancer. NcRNAs also show promise as diagnostic biomarkers and prognostic indicators. Unraveling the complexity of the regulatory networks governed by ncRNAs in skin cancer offers unprecedented opportunities for groundbreaking targeted therapies, revolutionizing the landscape of dermatologic care.
Keyphrases
- skin cancer
- gene expression
- cell cycle
- transcription factor
- long non coding rna
- genome wide identification
- cell proliferation
- dna methylation
- genome wide analysis
- network analysis
- signaling pathway
- healthcare
- stem cells
- poor prognosis
- quality improvement
- palliative care
- genome wide
- oxidative stress
- big data
- amino acid
- protein protein
- binding protein
- heat shock protein
- chronic pain