Nuclear factor of activated T-cells 5 is indispensable for a balanced adaptive transcriptional response of lung endothelial cells to hypoxia.
Hebatullah LabanSophia SiegmundKatharina SchlerethFelix A TrogischAlia AbliehLennart BrandenburgAndreas WeigertCarolina de la TorreCarolin MoglerMarkus HeckerWolfgang M KueblerThomas KorffPublished in: Cardiovascular research (2024)
Collectively, our study shows that early and transient subpopulation-specific responses of MLEC to hypoxia may determine the degree of organ dysfunction in later stages. In this context, NFAT5 acts as a protective transcription factor required to rapidly adjust the endothelial transcriptome to cope with hypoxia. Specifically, NFAT5 restricts HIF1α-mediated Pdgfb expression and consequently limits muscularization and resistance of the pulmonary vasculature.