Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model.
Elizabeth A ProctorShauna M DineenStephen C Van NostrandMadison K KuhnChristopher D BarrettDouglas K BrubakerMichael B YaffeDouglas A LauffenburgerLisa R LeonPublished in: Journal of thrombosis and haemostasis : JTH (2020)
Heat stroke-induced coagulopathy may be a driving mechanistic force in heat stroke pathology, especially when exacerbated by prior infection. Coagulation markers may serve as accessible biomarkers for heat stroke severity and therapeutic strategies.