Knockdown of long non-coding RNA SOX2OT downregulates SOX2 to improve hippocampal neurogenesis and cognitive function in a mouse model of sepsis-associated encephalopathy.

Jialin YinYanan ShenYanna SiYuan ZhangJiayue DuXiajuan HuMengmeng CaiHongguang BaoYan Xing

Published in: Journal of neuroinflammation (2020)

SOX2OT knockdown improves sepsis-induced deficits in hippocampal neurogenesis and cognitive function by downregulating SOX2 in mice. Inhibiting SOX2OT/SOX2 signaling may be effective for treating or preventing neurodegeneration in sepsis-associated encephalopathy.

Keyphrases

transcription factor
long non coding rna
stem cells
intensive care unit
acute kidney injury

mouse model
septic shock
poor prognosis
cerebral ischemia

traumatic brain injury
early onset
signaling pathway
metabolic syndrome

endothelial cells
blood brain barrier
subarachnoid hemorrhage
high fat diet induced