Single nucleotide polymorphisms and microsatellites in the canine glutathione S-transferase pi 1 (GSTP1) gene promoter.

James C SaccoSarah MannKeller Toral

Published in: Canine genetics and epidemiology (2017)

Dogs and other canids exhibit extensive variation in the GSTP1 promoter. Genetic polymorphisms within distinct haplotypes prevalent in certain breeds can affect GSTP1 expression and carcinogen detoxification, and thus may be useful as genetic markers for cancer in dogs.

Keyphrases

dna methylation
genome wide
copy number
transcription factor
papillary thyroid
gene expression
poor prognosis
squamous cell
genome wide identification
binding protein
genetic diversity
lymph node metastasis
genome wide analysis