The Epigenomic Analysis of Human Obesity.
Christopher G BellPublished in: Obesity (Silver Spring, Md.) (2018)
This review primarily examines epidemiological or population-based studies of epigenetic modifications in relation to adiposity traits, as opposed to animal or cell models. It discusses recent work exploring the epigenome with respect to human obesity, which to date has predominately consisted of array-based studies of DNA methylation in peripheral blood. It is of note that highly replicated BMI DNA methylation associations are not causal, but strongly driven by coassociations for more precisely measured intertwined outcomes and factors, such as hyperlipidemia, hyperglycemia, and inflammation. Finally, the potential for the future exploration of the epigenome in obesity and related disorders is considered.
Keyphrases
- dna methylation
- insulin resistance
- genome wide
- weight gain
- high fat diet induced
- metabolic syndrome
- weight loss
- endothelial cells
- gene expression
- peripheral blood
- type diabetes
- high fat diet
- body mass index
- pluripotent stem cells
- induced pluripotent stem cells
- adipose tissue
- oxidative stress
- skeletal muscle
- copy number
- single cell
- stem cells
- high throughput
- risk assessment
- bone marrow
- human health
- glycemic control