Dupilumab improves outcomes in patients with chronic rhinosinusitis with nasal polyps irrespective of gender: results from the SINUS-52 trial.
Wytske J FokkensClaus BachertClaire HopkinsOsama MarglaniAmy PraestgaardScott NashYamo DenizPaul J RoweHarry SacksJuby A Jacob-NaraPublished in: Clinical & translational immunology (2024)
Female patients had greater asthma, NSAID-ERD and HRQoL burden at baseline than male patients. Dupilumab treatment significantly improved objective and subjective outcomes compared with placebo, irrespective of gender.
Keyphrases
- end stage renal disease
- chronic rhinosinusitis
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- mental health
- clinical trial
- chronic obstructive pulmonary disease
- randomized controlled trial
- atopic dermatitis
- type diabetes
- adipose tissue
- risk factors
- phase iii
- weight loss