NRF2 Activation in Trp53;p16-deficient Mice Drives Oral Squamous Cell Carcinoma.

Samera H Hamad Rani S Sellers Nathan Wamsley Paul Zolkind Travis P Schrank Michael B Major Bernard E Weissman

Published in: Cancer research communications (2024)

Human squamous cancers frequently show constitutive NRF2 activation, associated with poorer outcomes and resistance to multiple therapies. Here, we report the first activated NRF2-driven and human-relevant mouse model of squamous cell carcinoma that develops in the background of p16 and p53 loss. The availability of this model will lead to a clearer understanding of how NRF2 contributes to the initiation, progression, and therapeutic response of OSCC.

Keyphrases

oxidative stress
endothelial cells
squamous cell carcinoma
mouse model
induced pluripotent stem cells
pluripotent stem cells
type diabetes
high grade
skeletal muscle
radiation therapy
young adults
insulin resistance
locally advanced
glycemic control