The protective role of rs56103835 against breast cancer onset in the Iranian population.

The C allele is likely to inhibit the expression of BRCA2 by interfering with the processing of this pre-miRNA and increasing the expression of target genes such as BRCA2. Because one of the early onset genes in breast cancer is the BRCA2, the presence of any of C and T alleles can have a significant effect on the incidence of the disease. To further confirm this data, however, more molecular studies are needed.