Genome-wide meta-analysis identifies susceptibility loci for autoimmune hepatitis type 1.

You LiYing SunYanmin LiuBangmao WangJia LiHanxiao WangHaiping ZhangXiaoyi WangXu HanQiuxiang LinYang ZhouLilin HuYuhu SongJie BaoLing GongMengying SunXiaoling YuanXinhe ZhangMin LianXiao XiaoQi MiaoQixia WangKe-Ke LiShiyu DuAnlin MaYiling LiJie XuShanhong TangJunping ShiYun XuLing YangJiming ZhangZuxiong HuangLu ZhouYong CuiMichael F SeldinM Eric GershwinHuiping YanZhengsheng ZouXianbo ZuoRuqi TangXiong Manull null

Published in: Hepatology (Baltimore, Md.) (2022)

Our study identifies two novel loci (CD28/CTLA4/ICOS and SYNPR) exceeding genome-wide significance and suggests four loci as potential risk factors. These findings highlight the importance of costimulatory signaling and neuro-immune interaction in the pathogenesis of AIH.

Keyphrases

genome wide
dna methylation
risk factors
systematic review
copy number
multiple sclerosis
meta analyses
gene expression
randomized controlled trial
risk assessment
drug induced
genome wide association study