Angiotensinogen rs5050 germline genetic variant as potential biomarker of poor prognosis in astrocytoma.

Alexander Perdomo-PantojaSonia Iliana Mejía-PérezNancy Reynoso-NoverónLiliana Gómez-Flores-RamosErnesto Soto-ReyesThalía Estefania Sánchez-CorreaLissania Guerra-CalderasClementina Castro-HernandezSilvia Vidal-MillánJosé Sánchez-CoronaLucía Taja-ChayebOlga GutiérrezBernardo Cacho-DiazRosa Maria Alvarez-GomezJuan Luis Gómez-AmadorPatricia Ostrosky-WegmanTeresa CoronaLuis Alonso Herrera-MontalvoTalia Wegman-Ostrosky

Published in: PloS one (2018)

In patients with astrocytoma, AGT rs5050 GG-genotype was associated with poor prognosis. We propose this germline genetic variant as a complementary biomarker, which can be detected practically and safely in blood samples or saliva.

Keyphrases

poor prognosis
long non coding rna
genome wide
dna repair
copy number
dna methylation
dna damage
oxidative stress