An IKK/NF-κB Activation/p53 Deletion Sequence Drives Liver Carcinogenesis and Tumor Differentiation.

Michael SvinarenkoSarah-Fee KatzUmesh TharehalliMedhanie A MulawHarald J MaierYoshiaki SunamiSarah K FischerYuexin ChenSabine HeurichLena ErkertAndrea TannapfelThomas WirthReinhold SchirmbeckThomas SeufferleinAndré Lechel

Published in: Cancers (2019)

In conclusion, activation of NF-κB/p65 mimicking chronic inflammation provokes the formation of liver carcinoma. Collateral disruption of Trp53 supports tumor progression and influences tumor differentiation and heterogeneity.

Keyphrases

oxidative stress
signaling pathway
lps induced
pi k akt
nuclear factor
poor prognosis
immune response