Genome-Wide Analysis Identifies IL-18 and FUCA2 as Novel Genes Associated with Diastolic Function in African Americans with Sickle Cell Disease.

Julio D DuarteAnkit A DesaiJustin R SysolTaimur AbbasiAmit R PatelRoberto M LangAkash GuptaJoe G N GarciaVictor R GordeukRoberto F Machado

Published in: PloS one (2016)

FUCA2 and IL18 are associated with diastolic function in SCD patients, and may be involved in the pathogenesis of the disease. Genetic polymorphisms within the FUCA2 and IL18 gene regions are also associated with diastolic function in SCD, likely by affecting expression levels of the genes.

Keyphrases

ejection fraction
genome wide analysis
left ventricular
blood pressure
genome wide
end stage renal disease
chronic kidney disease
newly diagnosed
poor prognosis
prognostic factors
heart failure
gene expression
dna methylation
genome wide identification
transcription factor