Immunogenicity of SARS-CoV-2 infection and Ad26.CoV2.S vaccination in people living with HIV.

Khadija KhanGila LustigMallory BernsteinDerseree ArcharySandile CeleFarina KarimMuneerah SmithYashica GangaZesuliwe JuleKajal ReedoyYoliswa MiyaNtombifuthi MthabelaNombulelo P MagulaRichard LessellsTulio de OliveiraBernadett I GosnellSalim Abdool KarimNigel GarrettWillem HanekomLinda Gail-BekkerGlenda GrayJonathan M BlackburnMahomed-Yunus S MoosaAlex Sigalnull null

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

The neutralization response of the Delta variant following Ad26.CoV2.S vaccination in PLWH with well controlled HIV was not inferior to HIV-negative participants, irrespective of past SARS-CoV-2 infection. In SARS-CoV-2 infected and non-vaccinated participants, HIV infection reduced the neutralization response to SARS-CoV-2, with the strongest reduction in HIV viremic individuals.

Keyphrases

sars cov
respiratory syndrome coronavirus
antiretroviral therapy
hiv positive
hiv infected
human immunodeficiency virus
hiv testing
hiv aids
hepatitis c virus
men who have sex with men
coronavirus disease