The prognostic role of p53 and its correlation with CDK9 in urothelial carcinoma.
Jędrzej BorowczakKrzysztof SzczerbowskiMateusz ManiewskiMarek ZdrenkaPiotr SłupskiHanna AndrusewiczJoanna Łysik-MiśkurkaPaula RutkiewiczMagdalena BodnarŁukasz SzylbergPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2022)
High expression of p53 correlates with unfavorable clinical features of bladder cancer. CDK9 is associated with the expression of p53, possibly through interactions with p53 inhibitors. Since the blockade of CDK9 in other malignancies reactivates wild-p53 activity, confirming the crosstalk between p53 and CDK9 in bladder cancer may be another step to explain the mechanism of tumor progression in its early stages.