Sexual-biased necroinflammation is revealed as a predictor of bevacizumab benefit in Glioblastoma.

Sara Hiller-VallinaLucia Mondejar-RuescasMarta Caamaño-MorenoBlanca Cómitre-MarianoDenisse Alcivar-LópezJuan M SepulvedaAurelio Hernández-LaínÁngel Pérez-NúñezBerta Segura-CollarRicardo Gargini

Published in: Neuro-oncology (2024)

This study provides a stratification based on the sexual differences in GBM, which associates the poor prognosis with the presence of immunosuppressive myeloid cells in the necrotic areas. This new stratification could change the current prognosis of GBM and identifies those who respond to BVZ treatment.

Keyphrases

poor prognosis
long non coding rna
induced apoptosis
mental health
bone marrow
acute myeloid leukemia
genome wide
immune response
gene expression
oxidative stress
cell death
smoking cessation
replacement therapy