Silencing of CD47 and SIRPα by Polypurine reverse Hoogsteen hairpins to promote MCF-7 breast cancer cells death by PMA-differentiated THP-1 cells.

Gizem BenerAlex J FélixCristina Sánchez de DiegoIsabel Pascual FabregatCarlos J CiudadVéronique Noé

Published in: BMC immunology (2016)

Our data support the usage of PPRHs to diminish CD47/SIRPα interaction by decreasing the expression of both molecules thus resulting in an enhanced killing of MCF-7 cells by macrophages, which might translate into beneficial effects in cancer therapy. These results indicate that PPRHs could represent a new approach with immunotherapeutic applications.

Keyphrases

breast cancer cells
induced apoptosis
cancer therapy
cell cycle arrest
poor prognosis
cell death
signaling pathway
big data
deep learning
data analysis