Psychosocial Risk Profiles and Colorectal Cancer Screening: a Latent Profile Analysis in a Colorectal Cancer Screening Intervention Setting.

Health behavior theories have identified predictors of colorectal cancer (CRC) screening. This study aimed to determine the psychosocial profiles of a predominantly Hispanic population of primarily Mexican origin receiving a CRC screening intervention and whether a specific combination of psychosocial profiles modified the effect of CRC screening intervention on CRC screening uptake. 467 participants aged 50 -75 years due for CRC screening received an educational intervention. Latent profile analysis was performed on baseline psychosocial constructs to identify the homogenous clustering of individuals with similar psychosocial constructs. In addition, CRC screening rates and changes in psychosocial scores between the latent groups were compared. Three psychosocial profiles, including a low benefit and high susceptibility group (LBHS), a high benefit and low susceptibility group (HBLS), and a high barrier and high susceptibility group (HBHS), were identified in this study. The HBLS group had the lowest susceptibility, with no improvement in benefits and barriers. This group had the lowest screening rate (80.85%) compared to 88.8% in LBHS and 86.3% in HBHS following the intervention. Finally, the intervention effect size on psychosocial score changes was smaller in HBLS than in other groups. This subgroup analysis suggests that CRC educational interventions should be tailored to improve the benefits and barriers among individuals with high susceptibility scores.