Low-dose lidocaine attenuates fentanyl-induced cough: A double-blind randomized controlled trial.
Nuanwan PhuvachoterojanaphokinGrit WatanaboonyongcharoenSarita JinawongSithapan MunjupongPublished in: European journal of clinical pharmacology (2022)
The study implied intravenous lidocaine 0.25 mg/kg for 2 min before fentanyl injection was the most effective dose to suppress FIC and could be applied in daily practice. Patients aged less than 40 years and nonsmoking were risk factors of FIC, regardless of sex and underlying disease.
Keyphrases
- low dose
- randomized controlled trial
- risk factors
- end stage renal disease
- high dose
- newly diagnosed
- ejection fraction
- primary care
- healthcare
- chronic kidney disease
- study protocol
- peritoneal dialysis
- prognostic factors
- high glucose
- physical activity
- systematic review
- drug induced
- oxidative stress
- patient reported outcomes
- endothelial cells