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Aplastic anemia secondary to propylthiouracil: A rare and life-threatening adverse effect.

Hira Ghazal ShaikhAmir KamranSoorih ShaikhPrerna Mewawalla
Published in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2018)
Aplastic anemia has been sparingly reported as an extremely rare complication of propylthiouracil. Further adding to the ambiguity is the unknown etiology and lack of specific therapy for the complication when attributed to propylthiouracil. The disease can carry an extremely poor prognosis if untreated, as proven by our case. Due to the same reasons, we recommend that further investigations be done to elucidate the pathogenesis and assist with treatment of the disease when caused by propylthiouracil.
Keyphrases
  • poor prognosis
  • long non coding rna
  • chronic kidney disease
  • allogeneic hematopoietic stem cell transplantation
  • iron deficiency
  • acute myeloid leukemia
  • combination therapy
  • smoking cessation