Effectiveness of allergen immunotherapy with house dust mite extract for pediatric bronchial asthma.
Masaaki HamadaKeigo SaekiIchiro TanakaPublished in: Immunotherapy (2024)
Aim: We compared the effectiveness of rush subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) using standardized house dust mite (HDM) extract for pediatric bronchial asthma (BA). Methods: We followed the pediatric BA treatment score during 3 years of treatment. We assessed the median time to no longer requiring long-term control pharmacotherapy (LTCP) for BA (LTCP-free). We compared the outcomes after adjustment for confounding factors and propensity score matching. Results: Patients in the HDM SCIT group achieved the LTCP-free status significantly earlier than those in the HDM SLIT group after adjustment for confounding factors and propensity score matching. Conclusion: Patients treated for pediatric BA with rush HDM SCIT had earlier onset of therapeutic effects than those with HDM SLIT.
Keyphrases
- allergic rhinitis
- randomized controlled trial
- chronic obstructive pulmonary disease
- end stage renal disease
- systematic review
- oxidative stress
- ejection fraction
- newly diagnosed
- chronic kidney disease
- health risk
- human health
- prognostic factors
- risk assessment
- health risk assessment
- air pollution
- patient reported outcomes
- drinking water
- patient reported