Long noncoding RNAs expression in gastric cancer.
Farbod EsfandiMohammad TaheriVahid Kholghi OskooeiSeyedeh Morvarid NeishabouriPublished in: Journal of cellular biochemistry (2019)
Long noncoding RNAs (lncRNAs) have been involved in the pathogenesis of several human cancers including gastric cancer. In the current study, we selected five lncRNAs namely NEAT1, TUG1, PANDA, UCA1, and GHET1 to assess their expressions in gastric cancer samples compared with adjacent noncancerous tissues (ANCTs) from the same patients. Some previous reports have shown contribution of these lncRNAs in gastric cancer. However, we aimed to explore their associations with patients' clinicopathological data and their potential as diagnostic biomarkers. Significant associations were found between site of primary tumor and relative expression of all lncRNAs in cancer samples compared with ANCTs. Besides, GHET1 relative expression was associated with lymph node status. The diagnostic power of GHET1 was higher from other lncRNAs. Combination of GHET1, TUG1, UCA1, and PANDA increased the diagnostic power and significance (AUC = 0.8; P < 0.0001). The current study supports participation of lncRNAs in the pathogenesis of gastric cancer and highlights their potential as diagnostic biomarkers.
Keyphrases
- poor prognosis
- end stage renal disease
- lymph node
- newly diagnosed
- chronic kidney disease
- network analysis
- endothelial cells
- genome wide analysis
- prognostic factors
- squamous cell carcinoma
- emergency department
- physical activity
- binding protein
- long non coding rna
- radiation therapy
- young adults
- machine learning
- patient reported outcomes
- papillary thyroid
- risk assessment
- rectal cancer
- human health
- lymph node metastasis
- sentinel lymph node
- patient reported