Epigenetic silencing of miR-342-3p in B cell lymphoma and its impact on autophagy.
Min Yue ZhangGeorge A CalinKit San YuenDong Yan JinChor-Sang ChimPublished in: Clinical epigenetics (2020)
Intronic miR-342-3p is co-regulated with its host gene EVL by tumor-specific promoter DNA methylation in B cell lymphoma. The tumor suppressor function of miR-342-3p was mediated via inhibition of pro-survival autophagy by targeting MAP1LC3B and downregulation of DNMT1 with demethylation and re-expression of tumor suppressor genes.
Keyphrases
- dna methylation
- genome wide
- signaling pathway
- cell death
- diffuse large b cell lymphoma
- endoplasmic reticulum stress
- gene expression
- copy number
- poor prognosis
- oxidative stress
- genome wide identification
- transcription factor
- cell proliferation
- binding protein
- mass spectrometry
- simultaneous determination
- high density
- anti inflammatory
- free survival
- genome wide analysis
- high resolution
- liquid chromatography
- solid phase extraction