Transcriptional signatures in human macrophage-like cells infected by Leishmania infantum, Leishmania major and Leishmania tropica.

Aurora DiotalleviFederica BrunoGermano CastelliGiuseppe PersicoGloria BuffiMarcello CeccarelliDaniela LigiFerdinando MannelloFabrizio VitaleMauro MagnaniLuca Galluzzi

Published in: PLoS neglected tropical diseases (2024)

The identification of pathways elicited by parasites causing VL or CL could lead to new therapeutic strategies for leishmaniasis, combining the canonical anti-leishmania compounds with host-directed therapy.

Keyphrases

endothelial cells
gene expression
induced pluripotent stem cells
bone marrow
mesenchymal stem cells
oxidative stress
pluripotent stem cells
smoking cessation
replacement therapy