Pirfenidone: A Promising Drug in Ocular Therapeutics.
Amol Chhatrapati BisenSristi AgrawalRamakrishna RayitiSachin Nashik SanapArpon BiswasAnjali MishraNeeraj Mohan GuptaRabi Sankar BhattaPublished in: Chemistry & biodiversity (2024)
Pirfenidone, initially indicated for lung fibrosis, has gone beyond its original purpose, and shown promise in eye care. This detailed review tracks its evolution from lung treatment to aiding eye healing as evidenced by published literature. Pirfenidone's multifaceted attributes extend to mitigating corneal fibrosis, inflammation, and trauma. Through rigorous investigations, its efficacy emerges in diabetic retinopathy, macular degeneration, and postoperative glaucoma interventions. As an unheralded protagonist, pirfenidone reshapes ocular care paradigms, inviting renewed research opportunities.
Keyphrases
- idiopathic pulmonary fibrosis
- diabetic retinopathy
- optical coherence tomography
- pulmonary fibrosis
- optic nerve
- healthcare
- palliative care
- quality improvement
- oxidative stress
- systematic review
- cataract surgery
- pain management
- patients undergoing
- physical activity
- small molecule
- affordable care act
- emergency department
- randomized controlled trial
- big data
- machine learning
- trauma patients
- wound healing
- artificial intelligence
- drug induced
- smoking cessation