Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization.
Camille A McAloneyRawan MakkawiYogesh BudhathokiMatthew V CannonEmily M RingwaltAmy C GrossMaren CamTatyana A MeyersRebekka DuhenAlexander E DaviesRyan D RobertsPublished in: Cellular oncology (Dordrecht) (2023)
Niche-derived growth factors drive MAPK activity and MCL1 expression in osteosarcoma, promoting metastatic colonization. Although later metastases produce less MCL1, they remain dependent on it. MCL1 is a promising target for clinical trials in both human and canine patients.
Keyphrases
- poor prognosis
- clinical trial
- squamous cell carcinoma
- signaling pathway
- small cell lung cancer
- end stage renal disease
- ejection fraction
- newly diagnosed
- pi k akt
- binding protein
- prognostic factors
- cell proliferation
- oxidative stress
- peritoneal dialysis
- long non coding rna
- induced pluripotent stem cells
- patient reported