Lnc-GAN1 expression is associated with good survival and suppresses tumor progression by sponging mir-26a-5p to activate PTEN signaling in non-small cell lung cancer.
Rui-Qi WangXiao-Ran LongNing-Ning ZhouDong-Ni ChenMei-Yin ZhangZhe-Sheng WenLan-Jun ZhangFa-Zhong HeZhi-Lin ZhouShi-Juan MaiHui-Yun WangPublished in: Journal of experimental & clinical cancer research : CR (2021)
Lnc-GAN1 is downregulated and associated with poor survival of NSCLC patients, and mechanistically acts as a tumor suppressor via sponging and inhibiting miR-26a-5p to upregulate PTEN. This study provides a potential prognostic biomarker and treatment target for NSCLC.
Keyphrases
- small cell lung cancer
- poor prognosis
- end stage renal disease
- signaling pathway
- cell proliferation
- ejection fraction
- pi k akt
- newly diagnosed
- advanced non small cell lung cancer
- chronic kidney disease
- prognostic factors
- free survival
- peritoneal dialysis
- long non coding rna
- brain metastases
- combination therapy
- climate change
- binding protein
- tyrosine kinase