Effects of blocking mGluR5 on primate dorsolateral prefrontal cortical neuronal firing and working memory performance.
Sheng-Tao YangMin WangVeronica GalvinYang YangAmy F T ArnstenPublished in: Psychopharmacology (2020)
The mixed effects of MTEP on cognitive performance may arise from opposing actions at pre- vs. post-synaptic mGluR5 in dlPFC. These data from monkeys suggest that future clinical trials should include low doses, and identification of potential subgroup responders.
Keyphrases
- working memory
- clinical trial
- prefrontal cortex
- transcranial direct current stimulation
- phase iii
- attention deficit hyperactivity disorder
- electronic health record
- current status
- big data
- bioinformatics analysis
- human health
- cerebral ischemia
- open label
- randomized controlled trial
- risk assessment
- machine learning
- data analysis
- brain injury
- subarachnoid hemorrhage
- double blind
- deep learning
- blood brain barrier