GATA6 deficiency leads to epithelial barrier dysfunction and enhances susceptibility to gut inflammation.

Federica LaudisiCarmine StolfiGerolamo BevivinoClaudia MarescaEleonora FranzèEdoardo TronconeElisabetta LolliIrene MarafiniDaniele PietrucciAdelaide TeofaniAntonio Di GraziaDavide Di FuscoAlfredo ColantoniAngela OrtenziAlessandro DesideriIvan MonteleoneGiovanni Monteleone

Published in: Journal of Crohn's & colitis (2021)

Reduced expression of GATA6 promotes intestinal barrier dysfunction thus amplifying intestinal inflammatory pathology.

Keyphrases

oxidative stress
transcription factor
poor prognosis
replacement therapy