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Thromboxane biosynthesis in cancer patients and its inhibition by aspirin: a sub-study of the Add-Aspirin trial.

Nalinie Joharatnam-HoganDuaa HatemFay H CaffertyGiovanna PetrucciDavid A CameronAlistair RingHoward G KynastonDuncan C GilbertRichard H WilsonRichard A HubnerDaniel E B SwinsonSiobhan ClearyAlex RobbinsMairead MacKenzieMartin W G Scott-BrownSharmila SothiLesley K DawsonLisa M CapaldiMark ChurnDavid CunninghamVincent KhooAnne C ArmstrongNicola L AinsworthGail HoranDuncan A WheatleyRussell MullenFiona J LoftsAxel WaltherRebecca A HerbertsonJohn D EatonAnn O'CallaghanAndrew EichholzMohammed M KagziDaniel M PattersonKrishna NarahariJennifer BradburyZuzana StokesAzhar J RizviGeorgina A WalkerVictoria L KuneneNarayanan SrihariAleksandra Gentry-MaharajAngela MeadeCarlo PatronoBianca RoccaRuth E Langley
Published in: British journal of cancer (2023)
Persistently increased thromboxane biosynthesis was detected after radical cancer therapy, particularly in colorectal and gastro-oesophageal patients. Thromboxane biosynthesis should be explored further as a biomarker of active malignancy and may identify patients likely to benefit from aspirin.
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