Characterising ALS disease progression according to El Escorial and Gold Coast criteria.
Adriaan D de JonghNathalie BraunMarkus WeberMichael A van EsPegah MasroriJan Herman VeldinkPhilip Van DammeLeonard H van den BergRuben P A van EijkPublished in: Journal of neurology, neurosurgery, and psychiatry (2022)
The GCC broaden the definition of ALS, allowing more patients to participate in trials, while minimally impacting population heterogeneity. Given the large variability per diagnostic category, selecting only specific categories for trials may not result in a more homogeneous study population.