Machine-Learning Analysis of Serum Proteomics in Neuropathic Pain after Nerve Injury in Breast Cancer Surgery Points at Chemokine Signaling via SIRT2 Regulation.
Jörn LötschLaura MustonenHanna HarnoEija A KalsoPublished in: International journal of molecular sciences (2022)
The identified proteins play important roles in immune processes such as cell migration, chemotaxis, and cytokine-signaling. They also have considerable overlap with currently known targets of approved or investigational drugs. Taken together, several lines of unsupervised and supervised analyses pointed to structures in serum proteomics data, obtained before and after breast cancer surgery, that relate to neuroinflammatory processes associated with the development of neuropathic pain after an intraoperative nerve lesion.
Keyphrases
- neuropathic pain
- machine learning
- cell migration
- spinal cord
- spinal cord injury
- minimally invasive
- coronary artery bypass
- big data
- mass spectrometry
- artificial intelligence
- surgical site infection
- oxidative stress
- electronic health record
- label free
- high resolution
- peripheral nerve
- patients undergoing
- randomized controlled trial
- deep learning
- percutaneous coronary intervention
- childhood cancer