Validation of Parametric Methods for [11C]UCB-J PET Imaging Using Subcortical White Matter as Reference Tissue.

Nathalie MertensRalph Paul MaguireKim SerdonsBrigitte LacroixJoel MercierDavid SciberrasKoen Van LaereMichel Koole

Published in: Molecular imaging and biology (2021)

SRTM2 is the preferred method for a voxelwise analysis of dynamic [11C]UCB-J PET using SO as reference tissue, while reducing the dynamic acquisition to 60 min has limited impact on [11C]UCB-J BPSO parametric maps. For a static PET protocol, both SUVRSO,60-90min and SUVRSO,50-80min images are an excellent proxy for [11C]UCB-J BPSO parametric maps.

Keyphrases

pet imaging
white matter
positron emission tomography
computed tomography
pet ct
multiple sclerosis
randomized controlled trial
deep learning
convolutional neural network
optical coherence tomography