Laundry detergents and surfactants-induced eosinophilic airway inflammation by increasing IL-33 expression and activating ILC2s.
Kyoko SaitoKeisuke OrimoTerufumi KuboMasato TamariAyako YamadaKenichiro MotomuraHiroki SugiyamaRyo MatsuokaNaoko NaganoYuka HayashiKen AraeMariko HaraMasashi IkutaniTatsuki FukuieKatsuko SudoAkio MatsudaYukihiro OhyaShigeharu FujiedaHirohisa SaitoSusumu NakaeKenji MatsumotoCezmi A AkdisHideaki MoritaPublished in: Allergy (2023)
The laundry detergents and surfactants-induced eosinophilic airway inflammation in vivo through epithelial cell and ILC2 activation. They induced IL-33 expression in airway epithelial cells through oxidative stress. Furthermore, detergent residues were present in house dust and are presumably inhaled into the airway in daily life.