Differential DNA Methylation Regions in Adult Human Sperm following Adolescent Chemotherapy: Potential for Epigenetic Inheritance.
Margarett ShnorhavorianStephen M SchwartzBarbara StansfeldIngrid Sadler-RigglemanDaniel BeckMichael K SkinnerPublished in: PloS one (2017)
This is the first observation in humans that an early life chemical exposure can permanently reprogram the spermatogenic stem cell epigenome. The germline (i.e., sperm) epimutations identified suggest chemotherapy has the potential to promote epigenetic inheritance to the next generation.
Keyphrases
- dna methylation
- early life
- stem cells
- gene expression
- genome wide
- mitochondrial dna
- endothelial cells
- locally advanced
- copy number
- young adults
- human health
- mental health
- dna repair
- squamous cell carcinoma
- childhood cancer
- risk assessment
- chemotherapy induced
- induced pluripotent stem cells
- pluripotent stem cells
- bone marrow