An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract.

Naoko Yamaguchi Ernest Whanwook Chang Ziyan Lin Akshay ShekharLei BuAlireza Khodadadi-Jamayran Aristotelis TsirigosYiyun CenColin K L Phoon Ivan P Moskowitz David S Park

Published in: Circulation (2023)

Our results using human and mouse models reveal an essential gene regulatory network of the OFT that requires an anterior second heart field enhancer to link GATA6 with NKX2-5-dependent rotation and septation gene programs.

Keyphrases

transcription factor
genome wide
heart failure
endothelial cells
binding protein
mouse model
atrial fibrillation
genome wide identification
left ventricular
induced pluripotent stem cells
copy number
dna methylation
network analysis