Synthesis of Tetrahydro[1,3,4]triazepines via Redox-Neutral α-C(sp3)-H Amination of Cyclic Amines.

Xiao-De AnKang DuanXian-Jiang LiJian-Ming YangYong-Na LuQing LiuJian Xiao

Published in: The Journal of organic chemistry (2019)

A Brønsted acid-catalyzed α-C(sp3)-H amination of cyclic amines using hydrazines as coupling partners has been reported. This methodology provides a unique protocol to the one-step assembly of tetrahydro[1,3,4]triazepines via [1,5]-hydride transfer-initiated C(sp3)-H amination. This reaction features mild conditions, good yields, and high atom economy.

Keyphrases

electron transfer
room temperature
randomized controlled trial
molecular dynamics
human immunodeficiency virus
hiv infected
ionic liquid
men who have sex with men