Segmental quantification of hepatic lipid content based on volumetric MRI data in patients with suspected iron overload.
Arthur P WunderlichHolger CarioStephan KannengießerVeronika GrunauMichael GötzFelix HüttnerJohanna BackhusMeinrad BeerStefan Andreas SchmidtPublished in: RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin (2023)
· A volumetric analysis of 3D MRI data of patients with suspected hepatic iron overload yielded a markedly elevated MR proton density fat fraction (MR-PDFF) in hepatic segments 1 to 3.. · This hepatic fat distribution, observed for the whole patient cohort, is similar to healthy living liver donors.. · The subgroup of patients with a high average MR-PDFF ≥ 6.5 % shows this effect with lower segmental deviations.. · In patients without fat metabolic disorders, the steatosis grade may be underestimated when taking biopsies in segment 8 or 7..
Keyphrases
- contrast enhanced
- adipose tissue
- magnetic resonance imaging
- magnetic resonance
- fatty acid
- electronic health record
- ejection fraction
- newly diagnosed
- computed tomography
- insulin resistance
- high fat diet
- clinical trial
- case report
- iron deficiency
- skeletal muscle
- patient reported
- open label
- study protocol
- high fat diet induced