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Integrative transcriptomic and genomic analyses unveil the IFI16 variants and expression as MASLD progression markers.

Do Yoon KimMasaud ShahJang Hyun KimJungMo KimYang-Hyun BaekJin-Sook JeongSang-Young HanYong Sun LeeGaeul ParkJin-Han ChoYoung-Hoon RohSung-Wook LeeGi-Bok ChoiJong Hoon ParkKyung Hyun YooRho Hyun SeongYeon-Su LeeHyun Goo Woo
Published in: Hepatology (Baltimore, Md.) (2024)
This study unveils a comprehensive understanding of MASLD progression through transcriptomic classification, highlighting the crucial roles of IFI16 variants. Targeting the IFI16-PYCARD-CASP1 pathway may pave the way for the development of novel diagnostics and therapeutics for MASLD.
Keyphrases
  • copy number
  • single cell
  • poor prognosis
  • rna seq
  • machine learning
  • deep learning
  • small molecule
  • long non coding rna
  • genome wide
  • network analysis