Integrative transcriptomic and genomic analyses unveil the IFI16 variants and expression as MASLD progression markers.

Do Yoon Kim Masaud ShahJang Hyun KimJungMo KimYang-Hyun BaekJin-Sook JeongSang-Young HanYong Sun LeeGaeul ParkJin-Han ChoYoung-Hoon RohSung-Wook LeeGi-Bok ChoiJong Hoon ParkKyung Hyun YooRho Hyun SeongYeon-Su LeeHyun Goo Woo

Published in: Hepatology (Baltimore, Md.) (2024)

This study unveils a comprehensive understanding of MASLD progression through transcriptomic classification, highlighting the crucial roles of IFI16 variants. Targeting the IFI16-PYCARD-CASP1 pathway may pave the way for the development of novel diagnostics and therapeutics for MASLD.

Keyphrases

copy number
single cell
poor prognosis
rna seq
machine learning
deep learning
small molecule
long non coding rna
genome wide
network analysis