Synthetically Lethal BMN 673 (Talazoparib) Loaded Solid Lipid Nanoparticles for BRCA1 Mutant Triple Negative Breast Cancer.

Gamze Guney EskilerGulsah CecenerUnal EgeliBerrin Tunca

Published in: Pharmaceutical research (2018)

As a result, our findings suggest that SLNs formulation strongly provides a synthetic lethal therapeutic potential in BRCA1 mutated sensitive and resistant TNBC cells.

Keyphrases

drug delivery
induced apoptosis
cell cycle arrest
wild type
breast cancer risk
endoplasmic reticulum stress
fatty acid
cell death
wound healing
pi k akt