Biological aging markers in blood and brain tissue indicate age acceleration in alcohol use disorder.
Lea ZillichMetin CetinElisabeth M HummelEric PoiselGabriel R FriesJosef FrankFabian StreitJerome Clifford FooLea SirignanoMarion M FriskeBernd LenzSabine HoffmannKristina AdorjanFalk KieferGeorgy BakalkinAnita C HanssonFalk W LohoffOlli KärkkäinenEloise KokPekka J KarhunenGreg T SutherlandConsuelo Walss-BassRainer SpanagelMarcella RietschelDirk A MoserStephanie H WittPublished in: Alcohol, clinical & experimental research (2024)
The present study is the first to simultaneously investigate epigenetic clocks, telomere length, and mtDNAcn in postmortem brain and whole blood samples in individuals with AUD. We found evidence for accelerated biological aging in AUD in blood and brain, as measured by Levine's epigenetic clock, and DNAmTL. Additional studies of different tissues from the same individuals are needed to draw valid conclusions about the congruence of biological aging in blood and brain.