A continuously efficient O 2 -supplying strategy for long-term modulation of hypoxic tumor microenvironment to enhance long-acting radionuclides internal therapy.
Jingchao LiTingting WangYuanfei ShiZichen YeXun ZhangJiang MingYafei ZhangXinyan HuYun LiDongsheng ZhangQianhe XuJun YangXiaolan ChenNian LiuXinhui SuPublished in: Journal of nanobiotechnology (2024)
Radionuclides internal radiotherapy (RIT) is a clinically powerful method for cancer treatment, but still poses unsatisfactory therapeutic outcomes due to the hypoxic characteristic of tumor microenvironment (TME). Catalase (CAT) or CAT-like nanomaterials can be used to enzymatically decompose TME endogenous H 2 O 2 to boost TME oxygenation and thus alleviate the hypoxic level within tumors, but their effectiveness is still hindered by the short-lasting of hypoxia relief owing to their poor stability or degradability, thereby failing to match the long therapeutic duration of RIT. Herein, we proposed an innovative strategy of using facet-dependent CAT-like Pd-based two-dimensional (2D) nanoplatforms to continuously enhance RIT. Specifically, rationally designed 2D Pd@Au nanosheets (NSs) enable consistent enzymatic conversion of endogenous H 2 O 2 into O 2 to overcome hypoxia-induced RIT resistance. Furthermore, partially coated Au layer afford NIR-II responsiveness and moderate photothermal treatment that augmenting their enzymatic functionality. This approach with dual-effect paves the way for reshaping TME and consequently facilitating the brachytherapy ablation of cancer. Our work offers a significant advancement in the integration of catalytic nanomedicine and nuclear medicine, with the overarching goal of amplifying the clinical benefits of RIT-treated patients.
Keyphrases
- newly diagnosed
- end stage renal disease
- reduced graphene oxide
- photodynamic therapy
- radiation therapy
- cancer therapy
- ejection fraction
- sensitive detection
- chronic kidney disease
- randomized controlled trial
- hydrogen peroxide
- early stage
- systematic review
- locally advanced
- papillary thyroid
- prognostic factors
- high dose
- stem cells
- drug delivery
- high intensity
- type diabetes
- radiation induced
- fluorescence imaging
- squamous cell
- gold nanoparticles
- mesenchymal stem cells
- squamous cell carcinoma
- insulin resistance
- visible light
- bone marrow
- metabolic syndrome
- adipose tissue
- young adults
- atrial fibrillation
- lymph node metastasis
- skeletal muscle
- weight loss
- catheter ablation
- metal organic framework
- childhood cancer