PPAR gamma and PGC-1alpha activators protect against diabetic nephropathy by suppressing the inflammation and NF-kappaB activation.
Siyi HuangYuanmeng JinLiwen ZhangYing ZhouNan ChenWeiming WangPublished in: Nephrology (Carlton, Vic.) (2024)
PPARγ and its coactivator PGC-1α actively participate in protecting against renal inflammation by regulating the NF-κB pathway, which highlights their potential as therapeutic targets for renal diseases.