Safety of high-dose amikacin in the first week of all-oral rifampicin-resistant tuberculosis treatment for the prevention of acquired resistance (STAKE): protocol for a single-arm clinical trial.

Jihad SnobreJoel GasanaJean Claude Semuto NgabonzizaIsabel Cuella MartinLeen RigoutsBart Karl JacobsEmeline de VironNatacha HerssensJean Baptiste NtihumbyAnnualithe KlibazayreClement NdayishimiyeArmand Van DeunDissou AffolabiCorinne S MerleClaude MuvunyiMarieke G G SturkenboomPatrick MigambiBouke C de JongYves MucyoTom Decroo

Published in: BMJ open (2024)

NCT05555303.

Keyphrases

high dose
clinical trial
mycobacterium tuberculosis
pulmonary tuberculosis
low dose
randomized controlled trial
stem cell transplantation
emergency department
double blind
placebo controlled
drug induced