Huanglian-Jiedu decoction promotes adipose thermogenesis in obese mice by suppressing the expression of HDAC3.

Pingyuan XuZiwei ZhuRuonan ZhouYaping WeiFangyuan XuLixuan ShenZiwei WangYingying XueXizhong YuJuan ZhaoJing YanYu JinPenghua FangWenbin Shang

Published in: Journal of ethnopharmacology (2024)

Therefore, these results suggest that HLJDD enhanced adipose thermogenesis and improved energy expenditure by inhibiting HDAC3, thereby increasing UCP-1 and PGC-1α expression. These findings amplified the mechanisms of HLJDD and its potential to treat obesity and related metabolic disorders.

Keyphrases

adipose tissue
insulin resistance
poor prognosis
metabolic syndrome
skeletal muscle
type diabetes
histone deacetylase
binding protein
weight loss
signaling pathway
long non coding rna
high fat diet induced
weight gain