One-Pot Reaction of Carboxylic Acids, Ynol Ethers, and m-CPBA for Synthesis of α-Carbonyloxy Esters.

A novel one-pot reaction of carboxylic acids, ynol ethers, and m-CPBA for the synthesis of α-carbonyloxy esters in the presence of Ag2O is described. This process provides a direct approach to α-carbonyloxy esters with the achievement of formation of three C-O bonds. The protocol is featured with readily available starting materials and broad substrate scope. Control reactions and isotope-labeling reactions were conducted to elucidate a plausible mechanism.